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News 11th February 2020 – Tablets: A General Formulation Overview Tablets continue to be one of the most popular pharmaceutical dosage forms, as with the right tablet formulation you can achieve: ease of handling and administration for patients, stability convenient packing options, and well-established cost-effective manufacturing processes which produce consistent quality products. However, there are … Read more

News 28th January 2020 – Tablets: A General Overview Tablets are one of the most popular dosage forms used in the pharmaceutical industry due to their: ease of handling and administration for patients, stability, convenient packing options and well-established cost-effective manufacturing processes which produce consistent quality products. However, there are also disadvantages to presenting a … Read more

News 14th January 2020 – Oral Solid Dosage Forms Containing Amorphous Spray Dried Dispersions: Choices for First in Human Studies The number of amorphous solid dispersions entering first in human (FIH) studies continues to increase, due to the growing number of novel APIs with a poor solubility profile, and associated bioavailability challenges. Spray drying is … Read more

News 12th December 2019 – Assessing Enabling Technologies using the UpperSolv™+ Screening Platform for Increasing Bioavailability Currently approximately 9 out of 10 new drugs entering clinical trials will fail before reaching approval. Many of these drugs will fail due to problems with ADME (absorption, distribution, metabolism and excretion) rather than lack of efficacy. One of … Read more

News 28th November 2019 – Selecting a Spray Dryer for Development Studies and Clinical Manufacture When customers initiate discussions with Upperton, one of the first questions we are asked is “which spray dryer(s) do you have and how much material can they produce?” Whilst these are very pertinent questions, the answer is not a simple … Read more

News 19th November 2019 – API Challenges during early formulation development, Part 2 There are many challenges that face companies taking a NCE into early stage feasibility testing and beyond. Some of these challenges are specific to the physical and chemical properties of the molecule in question (e.g. hard to handle API) whilst other challenges … Read more

News 2nd October 2019 – API Challenges in Early Stage Formulation Development, Part 1 There are many challenges that face companies taking an NCE into early stage feasibility testing and beyond. Some of these challenges are specific to the physical and chemical properties of the molecule in question whilst other challenges are related to the … Read more