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An Overview of Early Phase Clinical Manufacture Clinical trials are a critical step in pharmaceutical development, ensuring the safety and efficacy of new treatments before they reach patients. They involve a series of rigorously designed phases with specific objectives and regulatory requirements. Small pharma companies often benefit from partnering with Contract Development and Manufacturing Organizations … Read more

Clinical trials are one of the most important components of any drug development project; requiring careful planning and extensive funding. Clinical trials are conducted to improve the efficacy and quality of a drug, to determine the dose and dose escalation, and investigate toxicity. With approximately only 9% of new chemical entities garnering a commercial status, … Read more

One aspect of clinical trial manufacturing that often slips under the radar when designing, planning, and budgeting a clinical study is placebo manufacture. A placebo is defined as a substance given to someone who is told that it is a particular medicine: either to make that person feel as if they are getting better or … Read more

By 2020, 58% of all therapeutics in development are injectable, 29% oral and 4% inhaled including nasal delivery, and while nasal delivery may not be one of the most explored routes, it has the potential to offer an alternative delivery method for therapeutics with some specific advantages. Nasal delivery of drugs has traditionally been via … Read more

With the continued expansion of our tablet formulation development services, Upperton currently have a number of tablet dosage form development projects completed or in progress. Theses tablet / solid dosage form projects have encompassed a wide range of development activities from Active Pharmaceutical Ingredient (API) characterisation and feasibility studies through the application of enabling technologies, … Read more

Stages of Tablet Compression Equipment Used During Formulation and Process Development Tablets are one of the most popular dosage forms used in the pharmaceutical, nutraceutical and veterinary industries due to their ease of handling and administration, stability, convenient packing options and well-established cost-effective manufacturing processes which produce consistent quality products. Developing a tablet formulation from … Read more